OXIDATIVE STRESS IN EXPERIMENTAL HYPOTHYROIDISM: EFFECT OF MITOCHONDRIA TARGETED CURCUMINSUPPLEMENTATION

Abstract

Introduction: The study was investigated to ameliorative effects of curcumin against E.coli
infection induced hypothyroidism in mice. Female mice were E.coli induced intraperitoneal
and mitochondrial-targeted curcumin (mt-c) give orally.
METHOD: The present investigation was conducted, Mitochondrial targeted curcumin
synthesized by covalent linkage of curcumin with lipophilic cation. TPP (1.31 gm) reacted
with HBr (350 ml) precursor to obtain lipophilicity. Reverse osmosis (RO) water 200 μl in
(5×106
) E.coli, and DMSO (2% v/v) were injected in mice by intraperitoneal, after three days
100 μl mt-c (0.12 mg/100 μl), RO water and DMSO were induced in mice for seven days.
Control group mice for each experimental setup were given simultaneously RO water and
DMSO. RESULT: The thyroid gland weight of mice increased after bacterial toxicity and ameliorate
with mt-C its weight decrease, the level of T3 and T4 decerase against bacterial toxicity and
ameliorate with mt-C its level increased, Lipid peroxidation and Superoxide dismutase (SOD)
increased the level against bacterial toxicity and ameliorate with mt-C its value
decreased,where as level of GSH after toxicity decreased and ameliorate with mt-C its value
increased. CONCLUSION: The data suggest that effect of mt-c positive against E.coli toxicity on thyroid
gland, which could be direct involvement of mt-c on the thyroid gland of mice.