A REVIEW ON CLINICAL IMPLICATIONS OF MUSCULARCREATINE KINASE AND RESPONSE TO EXERCISE

Abstract

Creatine kinase is a controller of cellular homeostasis. CK and its cytosolic and mitochondrial
subunits is compartment specific which play their role in cardiac muscles, skeletal muscles,
brain and other tissues. Under situations of compromised cellular energy state of ischemia,
oxidative stress and calcium overload, mitochondrial Creatine kinase exquisites susceptibility
to oxidative modifications and the compensatory up regulation of its gene expression, in some
cases leading to accumulation of crystalline Mt-CK inclusion bodies in mitochondria that are
the clinical hallmarks for mitochondrial cytopathies.Asymptomatic hyper CK emiais an
incidental finding in a patient without muscle related symptoms or with only insignificant
nonspecific muscle symptoms like cramps, spasms and fatigue that do not significantly affect
daily life activities. The diagnosis of congenital muscular dystrophy requires the concurrence
of expertise in multiple specialties available in a few centres worldwide that have achieved
sufficient experience with the different CMD subtypes. Metabolic muscle disruption is seen
due to heavy exercise, researchers studied exercise related elevation of CK in different groups
on the basis of different factors effecting CK.