ULTRASONOGRAPHIC EVALUATION OF GALLBLADDER VOLUME IN TYPE 2 DIABETICS AND ITS CORRELATION WITH AUTONOMIC NEUROPATHY

Abstract

Aims and Objective: Ultrasonographic determination of gallbladder volume in type 2 diabetics with 5 to 10 year duration and it’s comparison with a control group, and correlation of gallbladder volume in type 2 diabetics with autonomic neuropathy. Materials and Method: Fifty cases of diabetes mellitus and 50 healthy controls were recruited for the study. A detailed history and physical examination were recorded. Laboratory investigations done were - fasting and postprandial blood sugar, glycosylated haemoglobin, and serum lipid profile. Autonomic neuropathy was determined by using simple non-invasive bedside tests. Fasting gallbladder volume was measured by ultrasonography (calculated by ellipsoid formula). Results: The mean fasting gall bladder volume has been detected as 29.20±12.74 ml in diabetics with a minimum value of 10 and maximum value of 78 ml. and 17.50±2.206 ml in control subjects. When type 2 diabetics were subgrouped according to the presence of autonomic neuropathy, higher gallbladder volumes were seen in patients with autonomic neuropathy. Conclusions: Cholecystomegaly, to a significant degree, was documented in type 2 diabetics in the present study. It emphasized that duration of diabetes in these cases were 5 to 10 years. Gall bladder volume enlargement in type 2 diabetics as a whole is significantly correlated with severity of autonomic neuropathy (p<0.001).The mean gall bladder volume in type 2 female diabetics is higher than that found in type 2 male diabetics, but the difference in the gall bladder volume between the two sub groups is not statistically significant (p>0.05).