GYNANDROBLASTOMA: AN EXTREMLY RARE CASE

Abstract

Gynandroblastoma is a rare tumor that shows histologic features of both a granulosa-theca cell
and a Sertoli-Leydig cell (androblastoma) tumor, which, when functional, is often
masculinizing.[1]Although originally thought to be a teratoma, it is now held that
gynandroblastoma may arise from undifferentiated gonadal mesenchymal tissue, which is
believed to be able to mature into either male or female sex-cord stromal structures.[2]It has also
been reported to occur in the ovary usually, rarely in the testis but has been reported with
juvenile-type granulosa cells.[3,4] Only scattered reports of ‘‘true’’ gynandrobastoma are present
in the literature, to our knowledge. Tumor should contain more than 10% of the minor
component to warrant the diagnosis of Gynandroblastoma.[5,6] The confusion with collision
tumors, SertoliLeydig tumors that have focal areas resembling granulosa cell elements, that
historically have led to an overdiagnosis ofGynandroblastoma.